Anticholinergic drugs - pills against sweating
by Dietmar Stattkus (comments: 0)
Anticholinergics belong to the so-called systemic therapy for morbidly excessive sweating. This is internally active substances that inhibit the function of the body's neurochemical transmitter acetylcholine. Cholinergically means in this context "responding to acetylcholine." Acetylcholine is the neurotransmitter ACh or short in the circuit of sweating, which ultimately communicates the signals to the sweat glands to release their secretions.
In administering such a drug, the pulses between the nerve ends to disabled sweat gland, so that the excessive excitation which leads to a high sweat production , is inhibited. The frequency of contact and of ACh receptor is expressed simplified reduced. They blocked the output of acetylcholine, so consequently the flow of sweat is reduced.
This sounds simple, but is in reality a highly complex process because many of the nerve endings parasympathetic nervous system via acetylcholine can be controlled. A purely selective process for the inhibition of the welding current is therefore not accessible. The effect of sweat reduction is usually at the expense of some unwanted side effects (dry mouth, fatigue, difficulty concentrating, fast or irregular heartbeat, stomach upset, constipation ...).
Primary is effectively a one anticholinergics in the treatment of Parkinson's disease. Approaching a Schwitzer incidence falls into the secondary indication of such drugs. Indication for the treatment of hyperhidrosis include mild to moderate cases of generalized sweating, therefore the shape of the hypersecretion, which covers the entire body. Schwitzer zonal phenomena such as axillary sweating or perspiration on the hands or feet and can be customized with other therapeutic methods to tackle effectively.
They are in Germany and in German-speaking agents known Bornaprinhydrochlorid (drug Sormodren ©) and Methanteliniumbromid (drug Vagantin ©).
Since it can occur with this drug treatment to serious side effects, a medical monitoring for dose adjustment and support is imperative.
The increase in body temperature, which is caused by the decrease of sweat glands in taking an anticholinergic may in athletes, particularly at extremely - or high-performance athletes, high physical exertion and heat and high humidity might be dangerous and have a negative impact on performance.